D-Dimer

During inflammation, leukocyte mediated damage to blood vessel walls can lead to vasculitis with activation of the coagulation cascade and thrombus formation. Fibrinolysis of the clot’s releases D-dimer protein fragments into the bloodstream. D-dimer may therefore be used to track inflammation and blood vessel damage in inflammatory conditions. 

Raised levels may be associated with recent injury or surgery, vasculitis, pregnancy, heart disease or infection.