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An important cellular and mitochondrial antioxidant involved in the quenching of both oxygen and nitrogen free radicals, it also has a role to play in recycling vitamins C and E within the cell.
It is involved in the phase II detoxification of heavy metals and POPs and production of prostaglandins and leukotrienes.
Composed of three peptides (cysteine, glycine and glutamic acid) de novo synthesis within the cell is primarily limited by the availability of the amino acid cysteine.
Low levels are associated with the development of a range of chronic diseases such as neurodegenerative diseases, CVD, hypertension, liver disease, COPD, asthma and autoimmune disease as well as loss of function with aging.