IgG, IgM and IgE are all B cell secreted antibodies measured in this panel. They are part of the gamma portion of the blood protein globulins and determine the different immune responses depending on the antibody. They are produced in response to pathogens and act as a marking or identifying line of defense. IgE binds to allergens and produces response to allergic signals indicating histamine and mast cell degradation and is involved in parasitic infections like helminths. IgM is responsible for pathogen elimination in the early stages of humoral activity before there is sufficient IgG. IgG has 4 forms and provides the majority of antibody responses to pathogens, it is the only antibody that can cross the placental barrier.