Vitamin B6 is needed as a cofactor in approximately 100 enzyme reactions in the body. Of these, amino transfer and decarboxylation reactions (needed for production of serotonin from tryptophan) are possibly the most prominent. It is needed for gluconeogenesis and also modulates steroid hormone activity through binding to hormone receptors. 

 

Low levels are associated with skin rashes, cracked and sore lips, glossitis, mood changes, weak immune system, fatigue, tingling in extremities, seizures, high homocysteine. 

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