At FunctionalDX we live by the maxim Blood doesn’t lie and we are constantly evolving our functional testing offering to provide the most advanced insights into your client’s state of health.
Blood is the gold standard in medical testing, and we are excited to be extending our range of products to include the new biological testing markers in partnership with GlycanAge.
GlycanAge have pioneered a range of at home blood spot tests which are at the forefront of understanding biological vs chronological ageing. With studies demonstrating its efficacy in providing more predictive accuracy for ageing and longevity than previously advocated markers of telomere length or gene methylation.
GlycanAge looks at ageing on a systemic level, through functional effectors that play a key role in our immune system (to promote or suppress inflammation) which contribute to inflammageing (ageing of our immune system).
Biological ageing is related to the health and function of our bodies at cellular level. By using the most advanced glycan biomarkers to access the state of our internal environment, we can identify the advancement of negative biochemical activity such as inflammaging on health status.
“Glycans are directly involved in the pathophysiology of every major disease… Additional knowledge from glycoscience will be needed to realize the goals of personalized medicine and to take advantage of the substantial investments in human genome and proteome research and its impact on human health.”
— US National Academies, 2012
GlycanAge is the first biological age test that has proven responsiveness to interventions that beneficially affect the biology of ageing. Using this test in conjunction with FunctionalDX to maximise your therapeutic interventions; personalise, prioritise and progress your client’s health to the next level, reverse the aging process, reduce the affects of dis-function and heal the body for optimal health
We are partnering with GlycanAge to offer two tests, GlycanAge and Glyco-Cardio Health Report, providing the ultimate investigation into inflammaging and longevity.
GlycanAge and Glyco-Cardio Health Report are valuable alone or as additions to any FunctionalDX panel to provide a wider view of a client’s health and cellular ageing. We recommend these tests alongside our Man Reset and Femme Reset Panels from our Age Well test category for the ultimate in longevity testing.
GlycanAge: The original biological aging test
Measures immunoglobulin G glycans (IgG), which are responsible for humoral immunity; including specific antigen binding for antigen neutralization, complement activation, target opsonization for phagocytosis, antibody-dependent cell-mediated cytotoxicity and hypersensitivity reactions.
Depending on the antigen the antibody is specific to, it can be involved either in protection from pathogens (in case of harmful non-self-antigens), or in damaging reactions such as autoimmune diseases (in case of self-antigens) and anaphylaxis (in case of non-harmful non-self-antigens).
Glyco-Cardio Health Report: Investigate your metabolic health
Concerned about metabolic disease and its impact on accelerating the ageing process?
GlycanAge have found that in a number of conditions glycans change before onset of symptoms and even a decade before onset of disease, indicating that the loss of inflammation-suppressing IgG glycome might be casual for some.
This has been seen in Diabetes (human study) and hypertension and insulin resistance (animal study), followed by a study on 2000 twins in three time points across 15 years that indicated predictive power of IgG glycome composition for future development of hypertension (publication pending).
Our immune system keeps us alive and IgG glycome composition has been found to be associated with life expectancy in 27 different countries. Associations have also been found to correlate with the development index in the individual countries, meaning part of it is socioeconomic, even in the UK life expectancy can vary by 17 years based on your postcode (it went from 10-to-17yrs since covid).
*Please note Glyco-Cardio Health Report is currently only available for Women