Essential Thyroid markers
According to the British Thyroid Foundation, 1 in 20 people in the UK suffers from thyroid disorders. However, this doesn’t tell the whole story as often thyroid disorders go undiagnosed. Why? Doctors believe this could be down to 2 main reasons. Firstly, mild cases of hypo- or hyperthyroidism don’t necessarily have symptoms, and secondly, when they do, they appear so slowly, that people misattribute them to other things.
Undiagnosed thyroid disorders can create a greater strain on various bodily functions. Thyroid imbalances can often go undetected when certain crucial markers are not taken into account during testing.
Identifying thyroid dysfunctions can reveal key information on imbalances within skin and hair, support weight management, and drastically improve mood and energy levels.
Our comprehensive Thyroid CHECK offers the full spectrum of thyroid markers including T4, free T4, T3, Free T3, Reverse T3, T3 Uptake, many ratios and also includes glucose and a full blood count to accurately identify and ‘ check’ for subclinical disorders and help assess thyroid gland function.
The rate of sedimentation of red blood cells in anti-coagulated blood in one hour. Levels may indicate tissue destruction, inflammation, and may indicate in certain cases presence of pathogens.See full description
The portion of triiodothyronine (T3) that is not bound and represents approximately 10% of circulating T3 in the blood. T3 is converted from T4 and the majority occurs in the liver and kidneys. The conversion process is dependent on Selenium and bile levels. Levels can be used to assess Hypo and hyper thyroid status, T4 to T4 conversion efficacy, Selenium sufficiency, and Iodine sufficiency.See full description
Less than 0.05% of Total Thyroxine (T4) is free or unbound. The hormone is made in the thyroid gland and is the precursor to T3. Production of T4 is dependent on levels of iodine, co factors like B6, Biopterin, Copper, Zinc, Vitamins B2, B3 and A. Considered by mainstream when combined with TSH to be the gold standard for assessing thyroid function., Levels are assessed to identify thyroid status (hypo and hyper), Iodine sufficiency as well as protein status and liver function.See full description
Considered to be the metabolic brake to counteract the effects of the metabolic accelerator that is T3. Levels are used to identify possible diabetes, effects of fasting, heavy metals, inflammatory, pathogen effects, inflammatory cytokines like IL6 and TN-Alpha, also an indicator of stress.See full description
Used to assess thyroid hormone conversion, stress, elevated cortisol.See full description
Also known as T3 resin uptake. Measures the number of unbound sites on the thyroid binding proteins. Levels are used to identify thyroid states (hypo and hyper) as well as selenium and iodine sufficiency. Can also be used to identify how much binding globulins are available to bind to thyroid hormones.See full description
A marker to determine how much active T4 is available ie how well the thyroid is functioning. Used to determine hypo and hyper thyroid status.See full description
Also known as TG Abs. Used to determine if there is a thyroid autoimmune dysfunction ie Hashimoto’s (Hypo) or Graves (hyper) where the thyroglobulin in the thyroid is attacked.See full description
Also known as TPO. TPO is a thyroid gland produced enzyme that attaches the Iodine molecule to tyrosine to make T4. Levels are used to determine an autoimmune thyroid condition - Hashimoto’s.See full description
Represents the total of free and bound T3 in the blood, represents approximately 90% of T3. A small percentage is made directly in the thyroid gland and rest predominantly made in the liver and kidney by the conversion of T4 to T3. Levels are used to determine T4 conversion syndrome, Euthyroid sick syndrome, Selenium and Iodine sufficiency and Hyperthyroidism.See full description
Major thyroid hormone secreted by the thyroid gland and subject to appropriate levels of Biopterin, Vitamins B6, B2, A, B3 and C as well as sufficient Copper and Zinc. Total T4 represents over 99.5% of the total thyroid hormone available. Levels can help determine, thyroid status (hypo or hyper), Iodine sufficiency,See full description
Thyroid Stimulating Hormone is secreted from the anterior pituitary gland and levels are based on a negative feedback loop to signal to the thyroid gland whether to release more Thyroxine or stop releasing. Conventionally along with free T4 the combination is considered the gold standard for assessing thyroid status. Levels are also affected by heavy metal burdens including Aluminium.See full description
You will need a main test first
LDH is made up of a number of enzymes that are contained in different body tissues. This test identifies the levels of the different LDH enzymes so tat the site of damage, dysfunction and imbalance can be identified.
Comprehensive Male Hormone panel to provide insight on hormone balance within the body. Hormone levels can impact on energy, sex drive, performance, sleep, concentration and much more
Comprehensive Female Hormone panel to provide insight on hormone balance within the body. Hormone levels can impact on energy, sex drive, performance, sleep, concentration and much more.
Investigation for identifying autoimmune disease on the TSH receptors usually prevalent in Grave's disease (90%).
IGF-1 used to establish Growth Hormone deficiency or excess dues to it stability during the day unlike GH.
An Epstein-Barr virus (EBV) antibodies investigation can indicate a current, recent, or past EBV infection. Including: IgG, IgM and Anti Nuclear Antigen (ANA)
An Helicobacter Pylori Antibodies investigation can indicate recent past or longer term past H. Pylori infection
Anti Mullerian Hormone investigation useful for understanding ovarian reserve and can be used in assessment of PCOS.
Serum measured unbound testosterone.
A measure of glycated protein formed between glucose and albumin and is a marker for glucose control over the past 3 to weeks. Levels may indicate blood sugar dysregulation.
Affects levels of insulin carbohydrate fat and protein levels. Used in supplemental form to assist CH2O metabolism. Note Cr exists in 2 forms Cr (VI) which is toxic and enters the red blood cells and Cr (III). Plasma test measures total Cr and to ID Cr (VI) it will be necessary to measure RBC Cr levels
Protein hormone produced in the bone cells (osteoblasts). Binds calcium and is involved in bone regeneration and formation. Once released into the blood can act like a hormone and has direct effects i.e. it affects the beta cells of the pancreas and in turn can increase insulin production
Alkaline phosphatase, is made of isoenzymes, each one relating to the tissues they are found including liver, bone, intestine, and placenta.
Reticulocytes are newly formed and immature red blood cells that are produced in the bone marrow. They are reported as a percentage of total Red Blood Cells and can be used as an indicator or an individual's ability to produce RBCs. Levels are used to assess the bone marrow’s response to anaemia. and the effects of supplementation in the case of B12, B6 and Folate anaemias.
C3 is Important for the body’s immune function and response to inflammation. The main function is to destroy bacteria and viruses. C4 is Important for the body’s immune function and response to inflammation originating from the HLA system
Glucose 6 Phosphate Dehydrogenase. An enzyme that catalyses the energy (glucose to pyruvate) producing pathway that supplies reducing energy by maintaining the level of NADPH by reducing NADP to NADPH and compound essential in the biosynthesis of fatty acids
Examines the levels of specific blood proteins the Globulins. These are divided into Albumin as well as Alpha 1, Alpha 2, Beta, and Gamma globulins
Type 1 diabetes investigation or latent autoimmune adult diabetes. GAD enzyme is required for the healthy function of the pancreas. The presence of Glutamic Acid Decarboxylase Autoantibodies indicates Type 1 diabetes. Can be used to assess if gestational diabetes is type 1. Also can indicate neurological disorders. Consider in relation to gluten sensitivity and coeliac disease
Measures the amount of lipoprotein associated phospholipase in the blood. Primarily associated with LDL which carried the Lp-PLA2 to the coronary artery walls activating an immune response making plaque. Levels are associated with increased risk of heart attack and stroke and is an excellent coronary marker
Measurement of IgG, IgM, IgE Immunoglobulins in investigations of the immune system
Copper transport protein binds 95% of circulating copper. Interacts with 120 other proteins. Is an acute phase protein and responds to inflammation and inflammatory diseases.
Known as ‘the stress hormone’ this steroid hormone plays an essential role in helping the body respond to stress, and regulates a wide range of body processes, including metabolism and immune response.
A more accurate measure of magnesium can be obtained via red blood cells which contain 2 – 3x more Mg than serum. Mg is a mineral necessary for energy production, muscle contraction, nerve function etc.
Also known as holotranscobalamin also see Vitamin B12. Active B12 accounts for approximately 10 to 20% of total B12 levels. Considered to be a more sensitive marker than serum B12 as it degrades faster serum B12 with a short life span.
Also known as DAO. Used in the assessment of histamine intolerance which can be caused by the deficiency of DAO or an imbalance between histamine and DAO.
Dihydrotestosterone (DHT) is a male sex hormone (androgen). Androgens are endogenous steroid hormones consisting of DHEA, Androstenedione, Testosterone and DHT. DHT is the most potent hormone amongst the androgens because it is not converted to estrogen, it is considered to be a pure androgen. It is created from testosterone via the action of the enzyme 5 alpha-reductase and is produced in the prostate gland, adrenal glands, liver, brain, and hair follicles. Its action is related to the tissue in which it is produced. It is a more potent hormone than testosterone (approx. 1% circulated feely as unbound), it has a slow dissociation (approx. 5x less than testosterone) and long half-life (2x affinity to the androgen receptors). During development and adult life in men, it promotes prostate growth, activity of the sebaceous glands, male pattern baldness and the development of characteristics that are typically associated with men (body hair, muscle growth, and a deep voice). In women DHT levels are associated with issues including hirsutism, amenorrhea, and increased acne.
Made in the liver comprising of both LDL and Apolipoprotein A. levels, is used to assess, and associated with hypothyroidism, low sex hormone, inflammation and tissue damage, autoimmunity PCOS and kidney and heart disease.
The hormone Dehydroepiandrosterone (DHEA) is an important precursor to hormones such as the sex hormones Progesterone, Testosterone and the Oestrogens. It is produced predominantly in the adrenal glands and is involved in the Fight or Flight stress response to resume a calm state after perceived danger/stress has passed. As the most abundant circulating steroid in the body, it has an inﬂuence on over 150 known repair functions in both the body and brain. Increased or decreased levels may lead to many common conditions in the endocrine, immune, cardiovascular, hormonal, and nervous systems.
Cancer Markers: CA19-9, CA125, CA15-3
Zinc is not stored in the body and dietary intake is essential. Zinc is involved in over 300 enzyme functions. Including the metabolism and function of carbohydrates, proteins and fats. As well involved in immune function, skin health and healing and senses of taste and smell amongst many. Levels are used to assess zinc status at a red blood cell level, hydrochloric acid production, male fertility, inflammation, copper status amongst many.
Our FDX Thyroid Check panel has been created to look further than the norm (traditional blood analysis) to reveal more about your client’s health picture and to identify areas to focus an effective treatment plan. FunctionalDX uses the world’s most advanced blood interpretation technology considers 13 body systems, 7 accessory systems, 7 macronutrient systems, 14 micro-nutrient deficiencies and 40 clinical dysfunctions.
Fasting blood draw required in the morning.