Comprehensive thyroid and body health function
The thyroid gland’s hormone function has a significant impact on overall health. Multiple diseases and disorders can be associated with thyroid functionality and can develop at any age. Thyroid dysfunction could lead to a range of health conditions such as metabolic syndrome, heart disease, diabetes, hormonal, and sex hormone imbalances.
As clinicians, we look to safeguard our clients’ health and wellbeing by monitoring optimal thyroid function and well as investigating whether the insufficiency in some of the thyroid markers may trigger further pathogenesis.
A zinc dependent enzyme, the major function of Alkaline Phosphatase, is to protect your intestinal tract against bacteria, aid in digestion, breakdown fats and some B vitamins, and promote bone formation. As its name suggests it depends on an alkaline environment and is found in all tissues in the human body, but mostly in bones, kidneys, liver, intestines, and placenta. Levels are used to assess zinc need, liver function, Vitamin C need or biliary obstruction as well as bone turnover.See full description
An enzyme found primarily in the liver, with small amounts in the heart, muscles, and kidneys. Levels may indicate liver disease, biliary issues, pancreatitis or alcoholism, fatty liver, need for B6.See full description
An intracellular enzyme found primarily in the liver and heart and to a lesser extent in skeletal muscle, kidneys and lungs. It is released into the bloodstream due to cellular or tissue damage. Levels may indicate cardiovascular disease, liver disease, alcoholism, hypothyroidism, viral infection with EBV or CMV, muscle injury or acute pancreatitis, need for B6.See full description
A measure of bilirubin that has been conjugated ie. made water soluble in the liver so it can be excreted in the bile. Levels may indicate liver dysfunction or biliary tract obstruction.See full description
A marker comprising the total of direct (conjugated) and indirect bilirubin. Formed from the breakdown of haemoglobin from red blood cells at the spleen and bone marrow. May be elevated due to excess red blood cell destruction, liver dysfunction, oxidative stress bile duct obstruction, Gilbert's Syndrome or zinc deficiency, oxidative stress, heavy metal load.See full description
45% of calcium is inactive and bound to albumin, of the rest 45% is free and active. The calcium test measures total calcium. Calcium an alkali earth metal is essential for muscle contraction, oocyte activations, bone and dental health, blood clotting, nerve impulse transmission, heartbeat regulation and intracellular fluid balance. Levels are used to assess calcium sufficiency, parathyroid function, hydrochloric acid, tissue cell damage, thyroid function, vitamin D sufficiency, Osteoporosis, acid base balance, ovarian function.See full description
A negatively charged (anion) electrolyte located in extracellular fluid that is needed for stomach acid production, maintaining electrical neutrality and pH balance. Along with sodium, chloride helps to regulate normal levels of water in the body. Levels may indicate metabolic acidosis or alkalosis, adrenal hyperfunction / stress or hypochlorhydria.See full description
Groups of enzymes that play a large role in energy production and found in tissues that use lots of energy i.e. heart, skeletal muscle and the brain. Levels are used to assess damage from the heart (MI), skeletal muscle damage and breakdown, brain damage, and muscle atrophySee full description
The hormone Dehydroepiandrosterone (DHEA) is an important precursor to hormones such as the sex hormones progesterone, testosterone and the oestrogens. It is produced predominantly in the adrenal glands and is involved in the Fight or Flight stress response to resume a calm state after perceived danger/stress has passed. As the most abundant circulating steroid in the body, it has an inﬂuence on over 150 known repair functions in both the body and brain. Increased or decreased levels may lead to many common conditions in the endocrine, immune, cardiovascular, hormonal, and nervous systems.See full description
A measure of the amount of iron stored in the body. The most sensitive test to assess iron deficiency. Levels may indicate haemochromatosis, excess iron intake, inflammation, oxidative stress, liver dysfunction, excessive blood loss or iron deficiency anaemia.See full description
A measure of the total amount of folate in the serum. Folate is needed to make red and white blood cells in the bone marrow, convert carbohydrates into energy, and produce DNA and RNA. Adequate intake is extremely important during periods of rapid growth such as pregnancy, infancy, and adolescence. Levels may indicate dietary insufficiency, malabsorption or anaemia, methylation status, anaemia. Consider links to biopterin pathways and links to neurotransmitters like dopamine and serotonin etc.See full description
An enzyme mainly found in the liver. Some production from kidney, prostate and pancreas, Levels may indicate liver or biliary obstruction, alcohol excessive use, Pancreatitis, pancreatic insufficiency, need for Vitamin B6 and magnesiumSee full description
A plasma protein with different subtypes produced by the liver and immune system. Some transport nutrients and some, called Immunoglobulins, help to fight infection. Levels may indicate digestive inflammation, immune insufficiency, Gastritis, Cancer, liver damage, heavy metals, chemical toxicity, immune activation including parasites, elevated oestrogen, Haemolytic Anaemia.See full description
Haemoglobin A1C measures the amount of glucose that combines with Haemoglobin (glycosylation) over the life of the red blood cells i.e. approximately 90 days. Levels therefore can identify long term glucose management and control as well as Hypoglycaemia. Unlike a fasting glucose test this marker does require fasting.See full description
LDH (Lactate Dehydrogenase) Measures the level of enzyme. LDH plays a part in energy (carbohydrate) production referring to the reversible lactate to pyruvate pathway. Levels can relate to issues with the 5 main tissues it is found in (see LDH Isoenzymes) and glycemic management,See full description
A measure of magnesium in the blood. Mg is a mineral necessary for energy production, muscle contraction, nerve function, maintenance of strong bones, protein and carbohydrate metabolism and over 300 enzymatic processes in the body. It is obtained through the diet and is absorbed in the small intestine and colon. Levels may indicate a deficiency due to malabsorption or digestive disorders.See full description
A positively charged (cation) electrolyte located primarily in the extracellular fluid necessary for muscle contraction, nutrient absorption, neurological functioning and maintaining pH balance and osmotic pressure. Levels may indicate adrenal dysfunction, kidney dysfunction or dehydration.See full description
The sum of total proteins, ie. comprised of albumin and globulin totals in the blood. Levels may indicate dehydration, malnutrition, amino acid need, inflammatory conditions, hypochlorhydria, kidney or liver disease.See full description
A type of lipid primarily obtained through diet and from the conversion of excess dietary calories into fat for storage. Levels may indicate excess CHO intake and an increased risk for cardiovascular disease, biliary and liver dysfunction, autoimmune processes, metabolic syndrome, insulin resistance, poor fat processing, hypo and hyper-thryoidism.See full description
Produced as the end product of purine breakdown. It is predominantly excreted via the kidneys Failure to excrete or overproduction can be implicated in kidney stones and gout. Used in assessing risks of gout atherosclerosis, oxidative stress, arthritis, kidney function, intestinal permeability, methylation function, detoxification issues.See full description
A measure of the total amount of B12 in the serum. B12 is essential in methylation, important for the nervous system and for red blood cell production. Levels may indicate low dietary intake, malabsorption, Hypochlorhydria, autoimmunity, Anaemia or excessive alcohol intakeSee full description
A measure of the level of 25 (OH) D in the blood. Vitamin D is essential for bone health, brain health and immune function. Levels may indicate a deficiency due to inadequate exposure to sunlight, genetics, insufficient dietary intake, or toxicity due to excessive supplementation; and can be associated with risks of Cancer, Hypertension, chronic pain and inflammation, Diabetes and Depression.See full description
You will need a main test first
LDH is made up of a number of enzymes that are contained in different body tissues. This test identifies the levels of the different LDH enzymes so tat the site of damage, dysfunction and imbalance can be identified.
Comprehensive Male Hormone panel to provide insight on hormone balance within the body. Hormone levels can impact on energy, sex drive, performance, sleep, concentration and much more
Comprehensive Female Hormone panel to provide insight on hormone balance within the body. Hormone levels can impact on energy, sex drive, performance, sleep, concentration and much more.
Investigation for identifying autoimmune disease on the TSH receptors usually prevalent in Grave's disease (90%).
IGF-1 used to establish Growth Hormone deficiency or excess dues to it stability during the day unlike GH.
An Epstein-Barr virus (EBV) antibodies investigation can indicate a current, recent, or past EBV infection. Including: IgG, IgM and Anti Nuclear Antigen (ANA)
An Helicobacter Pylori Antibodies investigation can indicate recent past or longer term past H. Pylori infection
Anti Mullerian Hormone investigation useful for understanding ovarian reserve and can be used in assessment of PCOS.
Serum measured unbound testosterone.
A measure of glycated protein formed between glucose and albumin and is a marker for glucose control over the past 3 to weeks. Levels may indicate blood sugar dysregulation.
Affects levels of insulin carbohydrate fat and protein levels. Used in supplemental form to assist CH2O metabolism. Note Cr exists in 2 forms Cr (VI) which is toxic and enters the red blood cells and Cr (III). Plasma test measures total Cr and to ID Cr (VI) it will be necessary to measure RBC Cr levels
Protein hormone produced in the bone cells (osteoblasts). Binds calcium and is involved in bone regeneration and formation. Once released into the blood can act like a hormone and has direct effects i.e. it affects the beta cells of the pancreas and in turn can increase insulin production
Alkaline phosphatase, is made of isoenzymes, each one relating to the tissues they are found including liver, bone, intestine, and placenta.
Reticulocytes are newly formed and immature red blood cells that are produced in the bone marrow. They are reported as a percentage of total Red Blood Cells and can be used as an indicator or an individual's ability to produce RBCs. Levels are used to assess the bone marrow’s response to anaemia. and the effects of supplementation in the case of B12, B6 and Folate anaemias.
C3 is Important for the body’s immune function and response to inflammation. The main function is to destroy bacteria and viruses. C4 is Important for the body’s immune function and response to inflammation originating from the HLA system
Glucose 6 Phosphate Dehydrogenase. An enzyme that catalyses the energy (glucose to pyruvate) producing pathway that supplies reducing energy by maintaining the level of NADPH by reducing NADP to NADPH and compound essential in the biosynthesis of fatty acids
Examines the levels of specific blood proteins the Globulins. These are divided into Albumin as well as Alpha 1, Alpha 2, Beta, and Gamma globulins
Type 1 diabetes investigation or latent autoimmune adult diabetes. GAD enzyme is required for the healthy function of the pancreas. The presence of Glutamic Acid Decarboxylase Autoantibodies indicates Type 1 diabetes. Can be used to assess if gestational diabetes is type 1. Also can indicate neurological disorders. Consider in relation to gluten sensitivity and coeliac disease
Measures the amount of lipoprotein associated phospholipase in the blood. Primarily associated with LDL which carried the Lp-PLA2 to the coronary artery walls activating an immune response making plaque. Levels are associated with increased risk of heart attack and stroke and is an excellent coronary marker
Measurement of IgG, IgM, IgE Immunoglobulins in investigations of the immune system
Copper transport protein binds 95% of circulating copper. Interacts with 120 other proteins. Is an acute phase protein and responds to inflammation and inflammatory diseases.
Known as ‘the stress hormone’ this steroid hormone plays an essential role in helping the body respond to stress, and regulates a wide range of body processes, including metabolism and immune response.
A more accurate measure of magnesium can be obtained via red blood cells which contain 2 – 3x more Mg than serum. Mg is a mineral necessary for energy production, muscle contraction, nerve function etc.
Also known as holotranscobalamin also see Vitamin B12. Active B12 accounts for approximately 10 to 20% of total B12 levels. Considered to be a more sensitive marker than serum B12 as it degrades faster serum B12 with a short life span.
Also known as DAO. Used in the assessment of histamine intolerance which can be caused by the deficiency of DAO or an imbalance between histamine and DAO.
Dihydrotestosterone (DHT) is a male sex hormone (androgen). Androgens are endogenous steroid hormones consisting of DHEA, Androstenedione, Testosterone and DHT. DHT is the most potent hormone amongst the androgens because it is not converted to estrogen, it is considered to be a pure androgen. It is created from testosterone via the action of the enzyme 5 alpha-reductase and is produced in the prostate gland, adrenal glands, liver, brain, and hair follicles. Its action is related to the tissue in which it is produced. It is a more potent hormone than testosterone (approx. 1% circulated feely as unbound), it has a slow dissociation (approx. 5x less than testosterone) and long half-life (2x affinity to the androgen receptors). During development and adult life in men, it promotes prostate growth, activity of the sebaceous glands, male pattern baldness and the development of characteristics that are typically associated with men (body hair, muscle growth, and a deep voice). In women DHT levels are associated with issues including hirsutism, amenorrhea, and increased acne.
Made in the liver comprising of both LDL and Apolipoprotein A. levels, is used to assess, and associated with hypothyroidism, low sex hormone, inflammation and tissue damage, autoimmunity PCOS and kidney and heart disease.
Cancer Markers: CA19-9, CA125, CA15-3
Zinc is not stored in the body and dietary intake is essential. Zinc is involved in over 300 enzyme functions. Including the metabolism and function of carbohydrates, proteins and fats. As well involved in immune function, skin health and healing and senses of taste and smell amongst many. Levels are used to assess zinc status at a red blood cell level, hydrochloric acid production, male fertility, inflammation, copper status amongst many.
Our FDX Thyroid Check panel has been created to look further than the norm (traditional blood analysis) to reveal more about your client’s health picture and to identify areas to focus an effective treatment plan. FunctionalDX uses the world’s most advanced blood interpretation technology considers 13 body systems, 7 accessory systems, 7 macronutrient systems, 14 micro-nutrient deficiencies and 40 clinical dysfunctions.
Fasting blood draw required in the morning.